With the aim of studying the protein level of HNRNPL in PC, one tissue microarray was employed and IHC staining showed that HNRNPL was mostly expressed in the nucleus of pancreatic cancer cells (Figures 2(a)-2(b)), which implied that HNRNPL might function similarly to other RBPs and participate in RNA splicing and metabolism. This evidence concerns the gene HNRNPL and pachyonychia congenita.