A recent study shows that in hypoxic tumor microenvironment of EOC, tumor associated macrophages- (TAMs-) derived exosomes induce chemotherapy resistance of tumor cells via delivering miR-223 and activating miR-223/ phosphatase and tensin homolog- (PTEN-) PI3K/AKT signaling pathway [50]. The gene discussed is AKT1; the disease is neoplasm.