(i) tumor-derived exosomal ITGs determine the metastatic sites of the primary tumor cells; namely, exosomal ITGα6β4 and -α6β1 are associated with lung metastasis, while ITGαvβ5 is associated with liver metastasis, and ITGβ3 is associated with brain metastasis. Here, ITGB3 is linked to neoplasm.