Pessolano et al. have studied the role of exosomal annexin A1 (ANXA1) in pancreatic cancer via the MIA PaCa-2 model and knock-out technology of clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9). The gene discussed is ANXA1; the disease is pancreatic neoplasm.