In addition, exosomal miR-25-3p from CRC cells can be internalized by HUVECs, which gives rise to decreasing expression of Krüppel-like factor 2 (KLF2) and KLF4 with the respective functions of inhibiting angiogenesis and maintaining the integrity of endothelial barrier [23]. This evidence concerns the gene KLF2 and colorectal carcinoma.