Tumor released-exosomal miR-221-3p promotes lymphangiogenesis and LN metastasis in cervical squamous cell carcinoma (CSCC) by its transmission to human lymphatic endothelial cells (HLECs), which results in the activation of miR-221-3p-vasohibin-1- (VASH1-) extracellular signal-regulated kinase (ERK)/serine/threonine-protein kinase Akt (AKT) signal axis [25]. This evidence concerns the gene VASH1 and skin squamous cell carcinoma.