These exosomes released from lung adenocarcinoma cells (LAC) transfer miR-142-3p to lung endothelial cells and fibroblasts, which promotes angiogenesis mediated by inhibiting TGFβR1 in endothelial cells and induces fibroblasts tumor-associated phenotypes but may be irrelevant to TGFβ signaling pathway [26]. This evidence concerns the gene TGFB1 and neoplasm.