CXCR5 and Stroke: In brain ischemia stroke model, some researchers found that infarct volume and proinflammatory M1 microglia/macrophage density are increased in CXCR5 knockout mice, suggesting that microglia-derived CXCL13 acting through CXCR5 might be involved in neuroprotection following stroke through recruiting B lymphocytes to the ischemic hemisphere and secreting IL-10 [18, 19].