At this moment, there are few available inhibitors for SAC components; these include CFI402257 and TC Mps1 12 against monopolar spindle 1 (MPS1) or TTK and the BI2536 and LY3295668 inhibitors of PLK1 and AurA, respectively, while CDC20 is highly expressed and poor prognostic factor therefore constitutes an attractive biomarker and therapeutic target in LC (Table 1). The gene discussed is TTK; the disease is laryngotracheoesophageal cleft.