KDM4A and infection: In other family of viruses, herpes simplex viruses (HSVs) use specific histone modifications to control viral gene expression during latency (Kubat et al., 2004), so that the initiation of infection requires the activity of histone demethylases LSD1 and JMJD2 to promote transcriptional activation of viral genes (Liang et al., 2013).