The severity of cerebellar abnormality in lissencephaly ranges from discrete midline hypoplasia to disturbed foliation and volume reduction (Ross et al., 2001), later being most commonly associated with the involvement the TUBA1A (Poirier et al., 2007) and RELN genes (Hong et al., 2000; Chang et al., 2007). The gene discussed is RELN; the disease is Lissencephaly.