Preliminary studies have been conducted in non-allergic children (62) and children with excessively high IgE levels (63) with positive encouraging results; a single study on uncontrolled asthmatic children <6 years is actually ongoing (Preventing Asthma in High Risk Kids study, NCT02570984) with the aim to evaluate the disease-modifying effect of anti-IgE therapy. Here, IGHE is linked to asthma.