Recently, a large number of evidences showed that HMGCS2, a regulatory point converting acetyl-CoA to ketone bodies in the pathway [10, 11], enhanced invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer [12] and represented a potential novel prognostic biomarker for ESCC patients [13]. This evidence concerns the gene HMGCS2 and colorectal cancer.