In order to investigate whether HMGCS2 of colorectal cancer cells regulate HUVEC cells tube formation to strengthen the above results in vivo, as shown in Figure 3(a), conditioned media (CM) from HT29 cells transfected with siRNA targeted HMGCS2 significantly increased tube formation compared with CM from HT29 cells transfected with siRNA-NC. The gene discussed is HMGCS2; the disease is colorectal cancer.