Together, the reduced cortical area, the increased abundance of OxPhos- and β-oxidation-related proteins and the decreased abundance of galectin-1, and Rho GDIa and GDIb, among others, may play a critical role in intrathymic proliferation, dysfunctional thymocyte differentiation and selection and defective T cell migration, all of which can contribute to exacerbate thymic atrophy observed in malnourished mice infected with L. infantum. This evidence concerns the gene LGALS1 and thymus atrophy.