Knockdown of O-glycosyltransferase GALNT3 resulted in increasing the expression of poorly differentiated pancreatic ductal adenocarcinoma (PDAC) markers and influencing the O-glycans (Tn and T) expression in EGFR and Her2 in PDAC cells (40). The gene discussed is GALNT3; the disease is pancreatic ductal adenocarcinoma.