B2M and neoplasm: β2M has been confirmed as a highly significant prognostic factor in each study in which it has been examined; it reflects tumor burden and renal impairment but, in this study, there were only 25 cases measured. All in the L.C MM patients group had high α2 globulin concentration, although, α2 may be relatively higher owing to a coexisting acute phase response (haptoglobin) or to preferential retention of larger molecules (α2-macroglobulin).