In addition, the up-regulated DEGs were significantly enriched in 12 pathways such as NF-kappa B signaling pathway including LYN, LY96, CCL4, CD14; ECM-receptor interaction pathway including CD44, COL6A3, COL1A2, FN1 and Amoebiasis pathway including COL1A2, ITGB2, CD14, FN1 (Table 3). The gene discussed is COL1A2; the disease is amebiasis.