We report a case of autosomal recessive spastic paraplegia type 76 due to heterozygous variants of <i>CAPN1</i> in an Argentinean subject.<h4>Case presentation</h4>A 38-year-old Argentinean female presented with progressive gait problems and instability of 15-year duration. Here, CAPN1 is linked to Autosomal recessive spastic paraplegia type 76.