Our data showed that AD model rats had dramatically impaired PI3K/Akt/GSK-3β signaling caused by Aβ25-35 and D-gal, including reduced p-PI3K, p-Akt, and p-GSK-3β (Ser9), while the rats treated with KXS or Hup A resulted in sufficient restoration of PI3K/Akt GSK-3β signaling (Figures 4(a) and 4(b)). This evidence concerns the gene GSK3B and Alzheimer disease.