Immunohistochemistry staining and western blotting analyses showed that the DN group had significantly elevated extracellular matrix production (type I collagen and fibronectin) and TGF-β1 level in the kidneys compared with normal control rats; however, low-energy ESWT prevented renal fibrosis in STZ-induced DN rats (Figures 1(f)–1(l)). Here, FN1 is linked to renal fibrosis.