Persistent ROS exposure in cancer cells may lead to cell adaptation via the abnormal activation of different redox-sensitive transcription factors including nuclear factor-κB (NF-κB), c-Jun, hypoxia-inducible factor-1 (HIF-1), and the nuclear factor erythroid 2-related factor 2 (NRF-2) whose functions are largely involved in the positive expression of different antioxidant enzymes (e.g., SOD, catalase, and GSH antioxidant systems) [3, 4]. Here, NFE2L2 is linked to cancer.