In particular, in breast cancer cells, our evidence demonstrated the transient activation of the PI3K/AKT signaling cascade by oxidative stress which culminates in NGB upregulation and in its localization mainly at the cytosolic compartment, where it could act as a direct ROS scavenger, behaving as a first barrier to the increased ROS levels (Figure 2) [58]. The gene discussed is NGB; the disease is breast cancer.