As a consequence, obtained data strongly sustain a key function of NGB in the E2 and NRF-2-dependent high antioxidant capacity of estrogen-responsive breast cancer cells, and they suggest a possible role of the globin in the cytosolic signaling pathway involved in the NRF-2 nuclear translocation and transcriptional activity (Figure 2) [71]. The gene discussed is NGB; the disease is breast cancer.