Those indicated that mutant p53 (H179R) (or R248Q and R155Q in kyse150) in Kyse 450 cells still played a role in gene regulation, in accordance with the findings from other laboratories [53], such as Dong et al., who demonstrated that the expression of p53 gain-of-function mutation R175H in endometrial cancer cells increased the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway [33]. Here, AKT1 is linked to endometrial cancer.