Despite the fact that 30% of obese subjects are considered metabolically healthy, a condition where insulin sensitivity, visceral fat content, and intima media thickness of the carotid artery are similar to healthy normal weight, the majority of obese patients were metabolically unhealthy, with an increased risk of cardiovascular problems, metabolic disorders, arterial hypertension, and chronic heart disease development [3]. This evidence concerns the gene INS and metabolic disease.