The metabolic dysfunction of adipocytes is the main cause of chronic inflammation in WAT, through the increasing expression of many biologically functional cytokines/chemokines considering the major mediators of inflammation in particular in obesity condition, like tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-8 (IL-8), and interleukin-17D (IL-17D) [3]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.