The hypomethylation of aldo-keto reductase family 1 member B1 and tissue inhibitor of metalloproteinase 2 genes in association with albuminuria has been reported in subjects with early stages of diabetic nephropathy [50], although we did not recognize a significant correlation between urine 5MedC and albuminuria levels in the univariate analysis in our cohort (Table S1). Here, AKR1B1 is linked to diabetic kidney disease.