NOS3 and Schnyder corneal dystrophy: We previously demonstrated that SCD exhibits antihypertensive effects by modulating nitric oxide (NO)/endothelin-1 signaling and increasing NO level as well as by protecting against H2O2-induced injury through the regulation of the endothelial nitric oxide synthase (eNOS)/NO pathway in human umbilical vein endothelial cells [9–13].