In this regard we analysed the effects of ISCADOR Qu, a ML-rich VE, Aviscumine, a recombinant ML-1, and native ML-1, isolated from mistletoe plants growing on ash trees, on glioma cell growth, proliferation, clonogenic survival, and their capability of working in synergy with tumor irradiation and TMZ-based chemotherapy. Here, ATP8A2 is linked to neoplasm.