Breast cancers that are initially self-detected are commonly found to share more aggressive phenotypic characteristics (e.g., higher grade, hormone receptor negative, larger tumor size, positive lymph node status, and triple-negative breast cancer [TNBC] subtype) compared to those initially clinically detected through screening mammography or during routine physical exams performed by a healthcare provider [15–24]. Here, NR4A1 is linked to breast cancer.