MC1R and melanoma: Table S2) did not reveal consistent explanation for variability in MITF level in melanoma cell lines. Focusing on upstream regulators of MITF expression and melanogenesis, several variants of MC1R were found (Suppl.  Table S3). Notably, only DMBC11 and DMBC12 cell lines harboured homozygous MC1RR151C alteration (rs1805007), which might partially explain low expression of MITF-M and melanogenesis-related genes.