Neither could Trummer et al. [51] in their short-term (8 weeks) study on vitamin D-deficient/insufficient hypertension patients using 2800 IU/daily of vitamin D. Thus, despite using a higher dose than was used in Ameri et al.'s study, those studies failed to detect any significant effect on IGF-1 in short-term or long-term period in vitamin D-deficient/insufficient subjects. The gene discussed is IGF1; the disease is hypertensive disorder.