Previous studies indicated that ox-LDL-induced LOX-1 activation could be inhibited by miR-590-5p [11, 12], and miR-590-5p agomir effectively prevented the development of atherosclerosis in ApoE−/− mice through attenuating lipid accumulation and proinflammatory cytokine secretion [13, 14]. Here, APOE is linked to atherosclerosis.