In another study, a similar mitochondrial-directed anti-oxidant, MitoTEMPO, reduced chronic (6 week) ozone-induced (2.5 ppm, 3 h, twice weekly) lung inflammation (BAL cells and IL-1β, KC/CXCL1 and IL-6) and oxidative stress but had no effect on emphysema (Lm) scores. Here, IL1B is linked to pulmonary emphysema.