The study revealed their specificity to nuclear antigens like gp210, PCNA, Ro/SSA, Sm/RNP, SS-A/SS-B etc. Even though AGS and SLE share several overlapping disease manifestations, ss/dsDNA specific antibodies were not detected in any of the AGS patient sera in this study (123). This evidence concerns the gene CALR and Aicardi-Goutieres syndrome.