Expression levels of TLR2, TLR7, TLR9, IFN-alpha, and LY6E (Sca-1) mRNAs in SLE patients are significantly higher than healthy controls, indicating contribution of TLR-MyD88 signaling pathways in the pathogenesis of human lupus (170). The gene discussed is LY6E; the disease is systemic lupus erythematosus.