The accumulated DNA stimulates the cGAS-STING-IRF3/7 pathway leading to massive type-I interferon production, because the deficiency of either cGAS (131)/ STING (160, 161)/ IRF3 or IRF7 (162)/AIM2 (161) can rescue the mice form prenatal anemia and severe arthritis. The gene discussed is IRF3; the disease is anemia (phenotype).