RNPC3 and systemic lupus erythematosus: However, in several SLE patients, due to the blocking effect of anti-RNP Abs or IFNs on TFAM, neutrophil-mtDNA is unable to dissociate from nucleoids, hence ox-mtDNA is retained within the neutrophils and expelled with NETs, which induces the production of type-I IFNs through pDCs (78).