A suggestive association with a SNP in the TSLP gene and severe asthma has been identified in genome-wide analysis of severe asthmatics in one study (24), and TSLP has been shown in a papain-model of asthma to illicit a type 2 response for which ILC2s were the dominant source of IL-13 and IL-5 (25). This evidence concerns the gene TSLP and asthma.