One potential explanation could be that the spatial environment and the high density of target cells in 3D format enhances NK cell activation by promoting MesobsFab mediated serial contacts between NK and tumor cells (37, 38) and/or the engagement of other activating receptors such as NKG2D or NKp46 which has been shown to trigger IFNγ secretion (39). Here, NCR1 is linked to neoplasm.