NLRP3 and myocardial infarction: The calcium sensing receptor (CaSR)/NLRP3 inflammasome through the phospholipase C-inositol phosphate 3 (PLC-IP3) pathway in M1 macrophages plays a pivotal role in accelerating cardiac remodeling after MI in rats, including promoting cardiac fibroblast phenotypic transversion and increasing collagen as well as extracellular matrix secretion (87).