In a rabbit model, PEDF reduced the activation of the NLRP3 inflammasome, supposedly by inhibiting mitochondrial division through the pigment epithelial-derived factor receptor/calcium-independent phospholipase A2 (PEDFR/iPLA2), indicating that PEDF can also be used as a treatment strategy for ischemic diseases, including AMI and MI/R injury (117). This evidence concerns the gene SERPINF1 and ischemic disease.