Given that the region encompassing Sle1 on chromosome is a common susceptibility locus, additionally identified in NZB/W and in MRLlpr mice, and previous work showing TLR7 and MyD88 elimination preventing autoimmune phenotypes, we propose that IRAK kinase perturbations in these polygenic murine models would result in eliminating autoimmunity. The gene discussed is MYD88; the disease is Autoimmunity.