Furthermore, EBV-positive gastric carcinomas show an aberrant regulation of epigenetic markers of enhancers associated with angiogenic processes; these malignancies also display silencing of tumors suppressors and anti-angiogenic factors such as phosphatase and tensin homolog (PTEN) and thrombospondin (THBS) 1 (Kang et al., 2002; Okabe et al., 2017). This evidence concerns the gene PTEN and gastric carcinoma.