To functionally examine antiviral and proinflammatory innate immune responses to PV infection in vitro, we infected patient and control PBMCs and MdMs with PV and measured Type I IFN, CXCL10, and the proinflammatory cytokines TNFα and interleukin (IL)6. The gene discussed is CXCL10; the disease is acquired polycythemia vera.