However, another study in SLE patient proposed that LDGs arise as a consequence of in situ activation of normal neutrophils (Garcia-Romo et al., 2011), which was confirmed subsequently in a murine model of cancer, wherein NDGs exposed to transforming growth factor beta 1 (TGF-β1) were switched into LDGs (Sagiv et al., 2015). The gene discussed is TGFB1; the disease is cancer.