Moreover, given the stronger association between CTLA4 polymorphisms with AITDs than with T1DM (49), Ikegami et al. (50), demonstrating a stronger association of CTLA4 with T1DM complicated with AITDs than with T1DM without AITDs, suggested the possibility that the linkage between CTLA4 and T1DM could be due to the association of the CTLA4 polymorphism with coexisting AITDs (50). This evidence concerns the gene CTLA4 and type 1 diabetes mellitus.