Real time RT-PCR also showed that for the other six genes that NR2F1 (p = 0.034), KCNQ1 (p = 0.04), CD14 (p = 0.038), PTGER4 (p = 0.03), CY11B1 (p = 0.0037), and ESM1 (p = 0.0013) the mRNA expression was significantly altered in the ACC samples (Figure 13A). The gene discussed is ESM1; the disease is adrenal cortex carcinoma.