Immunoablation of FAP (fibroblast activation protein)-expressing cells led to the disappearance of myofibroblasts that express CXCL13 in the tumor stroma of androgen-deprived Myc-CaP tumors, reduced the infiltration of T cells, B cells and dendritic cells into the tumor remnants, and retarded the evolution of CRPC. The gene discussed is FAP; the disease is neoplasm.