A new gateway mechanism proposed for T-cell migration into the tumor involves their recruitment via high endothelial venules mediated by chemokine/chemokine receptor interactions, thus reinforcing the concept that recruitment of tumor specific T-cells to intratumoral tertiary lymphoid structures is mediated by the CXCL13:CXCR5 axis (82). Here, CXCL13 is linked to neoplasm.