Further, this study observed a greater proportion of activated (CD4+CD69+) T cell populations at the mesenteric lymph nodes of SIRT2 KO mice in response to DSS-induced colitis, indicative of enhanced inflammatory action (55), and ascribing a role for SIRT2, similar to SIRT1, in limiting CD4+ Teff cell inflammation. This evidence concerns the gene SIRT2 and colitis.