In a model of experimental allogenic bone marrow transplantation, total T cells from donor animals that exhibit a whole-body SIRT3 KO were less likely to promote graft-vs.-host disease relative to T cells from control mice, but did not affect the graft-vs.-tumor effect, suggesting that targeted inhibition of SIRT3 in allogenic T cells can improve outcomes after transplant (50). Here, SIRT3 is linked to neoplasm.