Figure 3 shows that the individuals with mutation of RAN rs14035, DOD more than 5 years and hypertension had a 40.60-fold higher possibility of suffering diabetic macrovascular complications when compared with the reference group (wild-type RAN rs14035, DOD <5 years and without hypertension) (OR: 41.60; 95%CI:11.75–147.35; P < 0.001). Here, RAN is linked to hypertensive disorder.