SOAT1 and infection: However, in contrast to what is observed during midgut infection of Ae. aegypti mosquitoes with SINV, a more recent study that investigated in more detail the early stages of infection of An. gambiae with ONNV revealed that the RNAi response was not important to control the primary infection of midgut cells with an infectious blood meal [in contrast to the immune deficiency (Imd) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathways; Carissimo et al., 2015].