RPS6KB1 and cardiac hypertrophy: Moreover, we also tested whether the observed cardioprotective effect of STS treatment would also depend on elimination of yet another main downstream targets of mTOR pathway, P70/S6K, which enhanced synthesis has been previously linked to deleterious cardiac hypertrophy that could be prevented by rapamycin pretreatment in several animal models of MI (McMullen et al., 2004b).