Moreover, we also tested whether the observed cardioprotective effect of STS treatment would also depend on elimination of yet another main downstream targets of mTOR pathway, P70/S6K, which enhanced synthesis has been previously linked to deleterious cardiac hypertrophy that could be prevented by rapamycin pretreatment in several animal models of MI (McMullen et al., 2004b). Here, MTOR is linked to cardiac hypertrophy.