Since the first therapeutic injection of a radioactive compound, nuclear medicine applications have been constantly evolving, and new targets like tumoral microenvironment immune checkpoint inhibitors (e.g., CTLA4 or PD1/PDL1 targets) still need to be explored in the field of glioblastoma treatment (Reardon et al., 2016; Huang et al., 2017). Here, CD274 is linked to glioblastoma.