AKT1 and neoplasm: Studies showed that 5,7-dihydroxyflavone, a dietary flavonoid that commonly exists in various plants, inhibited cell viability and induced apoptosis against human liver cancer HepG2 cells with minimal cytotoxicity to normal hepatocyte L-O2 cells in vitro and markedly suppressed the growth of HepG2 tumor xenografts in vivo via reducing the phosphorylations of Akt and STAT3 (Zhang Z. et al., 2013).