Another novel matrine derivative WM130 (C30N4H40SO5F) also significantly inhibited cell growth, migration, and invasion, and obviously induced apoptosis in liver cancer Huh-7 cells in vitro and markedly suppressed the tumor growth of Huh-7 xenografts in vivo through targeting PTEN/Akt pathway (Qian et al., 2015). Here, AKT1 is linked to neoplasm.