Furthermore, crocin also inhibited the cell growth and induced apoptosis and G0/G1 cell cycle arrest against leukemia HL-60 cells in vitro, and crocin at 6.25–25 mg/kg suppressed the growth of HL-60 tumor xenografts associated with the downregulation of Bcl-2 and upregulation of Bax increase in the tumor tissues in vivo (Sun et al., 2013). This evidence concerns the gene BCL2 and leukemia.