BCL2 and colonic neoplasm: Studies also demonstrated that B. javanica oil emulsion could induce apoptosis and inhibit autophagy in colon cancer HCT-116 cells (Yan et al., 2015) and induce apoptosis and G0/G1 cell cycle arrest by downregulating the expressions of p53 and Bcl-2 in liver cancer SMMC-7721 cells (Ma and Zhang, 2004).