BCL2 and breast carcinoma: Another study demonstrated that cordycepin promoted the activation of the pro-apoptotic factors of Bax and caspases-8, -9, and -3 and inhibited the anti-apoptotic factor of Bcl-2, and its effect on apoptosis induction was mainly via caspase-dependent pathways in human breast cancer MCF-7 and MDA-MB-231 cells (Wang D. et al., 2016).