Studies showed that 5,7-dihydroxyflavone, a dietary flavonoid that commonly exists in various plants, inhibited cell viability and induced apoptosis against human liver cancer HepG2 cells with minimal cytotoxicity to normal hepatocyte L-O2 cells in vitro and markedly suppressed the growth of HepG2 tumor xenografts in vivo via reducing the phosphorylations of Akt and STAT3 (Zhang Z. et al., 2013). Here, STAT3 is linked to liver cancer.