Further studies showed that oridonin at the concentrations of 12.5–100 μM significantly induced apoptosis against liver cancer MHCC97-H cells and the effect was related to decrease of the Bcl-2/Bax ratio and increase of the activity of caspases-3, -9, and Cyt-c (Zhu et al., 2013). This evidence concerns the gene CASP3 and liver cancer.