BCL2 and cancer: Furthermore, oridonin also significantly increased the cytotoxicity and/or reversed drug resistance of various anticancer drugs such as cisplatin, gemcitabine, and lentinan by downregulation of Bcl2 expression and upregulation of Bax expression in multiple human cancer cell lines including ovarian, pancreatic, and liver cancers (Liu D. L. et al., 2014; Ma et al., 2016; Xu T. et al., 2017).