Most notably, DHA, a derivative of artemisinin with better water solubility, has shown potent effects on cell growth inhibition and apoptosis induction by significantly inhibiting Jak2/STAT3 signaling activation and downstream target proteins in human head and neck cancer FaDu, liver cancer Hep-G2, colon cancer HCT-116, and tongue cancer Cal-27 cells (Jia et al., 2016; Wang D. et al., 2017). The gene discussed is STAT3; the disease is liver cancer.