BCL2 and glioblastoma: Another report also showed that a crude extract of cortex lycii radicis strongly inhibited the proliferation and migration of human glioblastoma cells in vitro and significantly induced apoptosis associated with increased proapoptotic factors caspase-3 and Bax, and decreased antiapoptotic factor Bcl-2 in glioblastoma tumors in vivo (Wang Q. et al., 2016).