BAX and liver cancer: Cinobufagin could inhibit cell growth and induce apoptosis by targeting apoptotic modulators including Bax, Cyt-c, and caspases (-3, -8, and -9) in prostate cancer LNCaP, DU145, and PC3 cells (Yu et al., 2008) and liver cancer HepG2 cells (Qi et al., 2011a).