Studies have shown that telekin at 2.5–10 μmol/L could significantly inhibit the cell proliferation by inducing cellular apoptosis via decreasing the expressions of Bcl-2 and Apaf-1, increasing the expression of Bax, releasing Cyt-c, and activating caspases-9 and -3 in liver cancer HepG2 cells (Zheng B. et al., 2013). Here, BAX is linked to liver cancer.