AKT1 and liver cancer: Silybin could inhibit cell growth and induce apoptosis by inhibiting PI3K/Akt-mTOR signaling pathway in various cancer cells including liver cancer Hep3B, cervical cancer HeLa, renal cancer 769-P, 786-O, OS-RC-2 and ACHN, glioma U87, and multiple myeloma U266 cells (García-Maceira and Mateo, 2009; Ma Z. et al., 2015; Zhang M. et al., 2015; Feng et al., 2016).