MAPK8 and liver cancer: Studies have shown that longikaurin A could inhibit cell growth, induce apoptosis and G2/M cell cycle arrest, and overproduce ROS in liver cancer SMMC-7721 cells in vitro and inhibited the growth of SMMC-7721 tumor xenografts in vivo via the regulation of ROS/JNK/c-Jun pathway (Liao et al., 2014).