Previous report revealed that SM, a steroidal alkaloid glycoside isolated and extracted from So. incanum, significantly induced apoptosis and G2/M cell cycle arrest with alteration of the Bcl-2/Bax ratio by downregulating antiapoptotic Bcl-2 and upregulating apoptotic Bax and caspases-3 and -9 in liver cancer SMMC7721 and HepG2 cells (Xie et al., 2015). This evidence concerns the gene CASP3 and liver cancer.