Oridonin also synergistically increased the cytotoxicity of Nutlin-3 [an inhibitor of murine double minute 2 (Mdm2)] against wild-type p53 osteosarcoma U2OS cells by enhancing cellular apoptosis via increasing the level of proapoptotic factor Bim and decreasing the levels of antiapoptotic factors Bcl-2 and Bcl-xl (Wang X. H. et al., 2017). The gene discussed is BCL2; the disease is osteosarcoma.