Crocin significantly inhibited cell proliferation and induced apoptosis against human osteosarcoma MG63 and OS732 cells at the concentrations of 0.5–4 mmol/L, and the effects of crocin on cytotoxicity and apoptosis were associated with the increased expression of caspases-3 and -8 (Li X. et al., 2013). The gene discussed is CASP3; the disease is osteosarcoma.