The ethanol extract of So. lyratum Thunb could significantly produce cytotoxicity and induce apoptosis via alteration of the Bcl-2/bax ratio by downregulating the level of Bcl-2 protein while upregulating the level of Bax protein in human osteosarcoma U-2 OS cells (Lin et al., 2013). Here, BAX is linked to osteosarcoma.