Studies have shown that MASM (6aS, 10S, 11aR, 11bR, 11cS)-10-methylamino-dodecahydro-3a,7a-diazabenzo (de), a novel derivative of matrine, markedly inhibited cell growth and induced apoptosis against human liver cancer Hep3B and Huh-7 cells in vitro and significantly suppressed the tumor growth of Huh-7 xenograft in vivo through inhibiting the PI3K/AKT/mTOR pathway (Liu Y. et al., 2017). Here, AKT1 is linked to liver cancer.