BCL2 and liver cancer: Moreover, the combination of H. diffusa Willd and clinically commonly used chemotherapeutic drug 5-flurourical could significantly inhibit the cell growth, induce apoptosis, and revise drug resistance by decreasing Bcl-2 expression and increasing Bax expression in colorectal cancer HCT-8 and liver cancer HepG2 cells (Chen et al., 2012; Li et al., 2018b).