CASP3 and osteosarcoma: Studies have shown that icariside II could also significantly inhibit the cell growth and induce apoptosis through upregulation of Bax, cleaved caspases-3, -7, -9, and poly (ADP-ribose) polymerasein, as well as downregulation of Bcl-2 in human osteosarcoma U2OS cells (Tang et al., 2017).