Protein chips results showed that RA have higher levels of anti-vascular endothelial growth factor (VEGF) A165 (P15692) antibodies than HC (P < 0.005); anti-VEGFA165 antibodies levels of patients with RA DP were lower than patients with RA NDP (P < 0.05); patients with RA DP have higher levels of anti-VEGFA165 antibodies than HC (P < 0.01). Here, VEGFA is linked to rheumatoid arthritis.