The serum levels of IL-6 in RA patients were significantly higher than subjects in HC (Diaz-Torne et al., 2018), and the DP was significantly lower than that in NDP (Peng et al., 2008).VEGFA165 plays a biological role by binding to its receptor subtypes, namely fms-like tyrosine kinase and neurohair protein-1 (Ferrara et al., 2003). This evidence concerns the gene IL6 and rheumatoid arthritis.