AKT1 and ovarian carcinoma: It was confirmed that PI3K/AKT/mTOR pathway-activated activities were accompanied by the downstream Foxo-3α, cyclin D1 and Bcl-XL (Akt), p-S6K1, and p-4E-BP1 (mTOR) as well as p21, p27, and PKCε in human ovarian cancer cells (Deeb et al., 2014b; Gao et al., 2014; Park and Kim, 2018).