In one previous study, significantly decreased levels of synaptophysin and PSD95 were observed in the hippocampus of sepsis mice at 24 h and 3 days following CLP (Moraes et al., 2014), while another study indicated that sepsis selectively decreased the levels of GluN2B but not synaptophysin at the first week after CLP or LPS (Zhang et al., 2017). Here, SYP is linked to Sepsis.