The latrophilins have been associated with various neuropsychiatric diseases, among those Attention-Deficit Hyperactivity Disorder (ADHD) has received particular attention, since multiple studies associate the Lphn3 gene with the etiology of the disease (discussed below) (Arcos-Burgos et al., 2010; Domene et al., 2011; Ribases et al., 2011; Jain et al., 2012; Labbe et al., 2012; Fallgatter et al., 2013; Acosta et al., 2016; Kappel et al., 2017; Huang et al., 2018). This evidence concerns the gene ADGRL3 and attention deficit-hyperactivity disorder.