Interestingly, a study investigating whether ADHD risk variants at the ADGRL3 locus interact with clinical, demographic, and environmental variables associated with SUD revealed that the presence of SUD in patients with ADHD can be predicted efficiently, thus identifying ADGRL3 as a risk gene for SUD (Arcos-Burgos and Velez, 2019). The gene discussed is ADGRL3; the disease is attention deficit-hyperactivity disorder.