Additionally, reduced hyperalgesia after electroacupuncture was associated with lower upregulation of NGF in a diabetes model (Manni et al., 2011) and decreased NMDA receptor phosphorylation (Tian et al., 2008) as well as lower density of the NMDA subunit (NR2B) in a model of irritable bowel syndrome (Liu et al., 2016). This evidence concerns the gene GRIN2B and diabetes mellitus.