In order to explore the functional role of miR-30-5p/TCF21 axis in atherosclerosis, five groups of the cell model were conducted: normal, blank, siNC, siTGF21, ox-LDL-treated THP-1 cells transfected with TCF21 siRNA and miR-30-5p inhibitor (siTCF21+inhibitor). The gene discussed is TCF21; the disease is atherosclerosis.