IR is activated by insulin, IGF-1(Insulin-like growthfactor) and IGF-II (Insulin growth factor-II) and any inequity inproduction or response of these factors adds to a cause in DM [10].Mono-ADP ribosyltransferase-sirtuin-6 (SIRT6) or Sirtuin-6 is astress receptive protein deacetylase and mono-ADP ribosyltransferase enzyme programmed by the SIRT-6 gene. Here, SIRT6 is linked to diabetes mellitus.